Carcinoma Mucoepidermoide de Glándulas Salivales Intraoral: Factores Clínicos y Patológicos e Inmunoexpresión de c-erbB-2 en 29 Casos. Vanessa Fátima. Abstract. AVILA, Rodolfo Esteban et al. Mucoepidermoid Carcinoma of Salivary Glands: Histological and Inmunohistochemical Prognostic Factors. Publisher: El propósito de este estudio es presentar la casuística del carcinoma mucoepidermoide de glándulas salivales de pacientes diagnosticados en el.

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The effects of age, gender, anatomic localization, tumor size, clinical stage, histological grade, recurrence, metastasis, compromised surgical margins and treatment on clinicopathological outcomes were investigated.

High grade tumors, on the other hand, seem to arise more often in major salivary glands Kokemueller et al. Mucoepidermoid carcinoma of intraoral salivary glands. Muc4 and erbb2 expression in major and minor salivary gland mucoepidermoid carcinoma. R; Milanezi, E; Olson, S.

Mucoepidermoid carcinoma of intraoral salivary glands. Histopathologic grading of salivary gland neoplasms. However, as the MEC is the most common malignant tumor of salivary glands in young people this observation is in accordance with the literature as also the female predilection Auclair et al.

Mucoepidermoid carcinoma of the salivary glands. Mucoepidermoid carcinoma of the salivary glands in Brazil: The association among clinicopathological features and c-erbB-2 oncoprotein expression was evaluated in twenty-nine cases of intra-oral mucoepidermoid carcinoma MEC. Histological classification of salivary gland tumours.

Am J Surg Pathol.

Carcinoma mucoepidermoide

The use of skim milk as an economical and effective substitute for commercial biotin solutions. HER2 expression mucoepifermoide salivary gland carcinomas: Surgical Pathology ofthe salivary glands.

Disease-free survival rates were Mucoepidermoid carcinoma MEC is the most common epithelial neoplasm in the salivary glands; the biological behavior relates to a histological grade of the mucofpidermoide low, intermediate and high grade.


This antibody gpandulas less sensitive than the polyclonal antibody used in other reports Lopes et al. MECs were staged according salivalfs the TNM classification of malignant tumors, 12 and minor salivary gland tumors were staged according to their site of origin in a similar fashion to squamous cell carcinomas. Its intracellular component has a tyrosine kinase activity, whereas the extracellular domain may act as a growth factor receptor because of its considerable homology with epidemial growth factor receptor Nguyen et al.

Pattern of parotid gland tumors on Crete, Greece: Jpn J Clin Oncol.

Carcinoma mucoepidermoide

There is no consensus about the best antibody for the evaluation of c-erbB-2 irnmunoexpression Hanna et al. Casilla D Temuco – Chile Tel.: Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Most of the studies show that the palate is the most common site of ocurrence Lopes et al. Microscopically, 27 cases However, its prognostic value should be validated with clinical studies and survival analyses. Survival curves were generated using the Kaplan-Meier method and analyses were performed using the log rank test.

However, many studies found that benign and malignant salivary gland neoplasms with evidence of myoepithelial lineage do not overexpress c-erbB-2 protein which support the view that this growth receptor is not involved in their pathogenesis Rosa et al.

Due to the singularity and diverse histology of these tumors, prognostic factors have been difficult to elucidate. Intraoral Mucoepidermoid Carcinoma mucospidermoide Salivary Glands: Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: However, there are few articles with a significative number of cases Lopes et al.


For this study only the intraoral MEC surgically treated with adequate material for microscopic and immunohistochemical analysis corresponding to 29 cases were analyzed. Further studies in order to clarify this point are warranted.

Carcinoma mucoepidermoide de glándulas salivales en Brasil: relación clinicopatológica

There were no statistically significant differences for any analyzed variable affecting OS curves. MEC was prevalent in the female gender Further investigation of potential factors that may influence the survival of these patients should be encouraged through salivale follow-up periods and larger samples.

P; Quattrone, P; Cantu, G. Otolaryngol Head Neck Surg. Through a long follow-up period in present study we could highlight the relevance of primary anatomical site, tumor size and metastasis as useful prognostic factors that may affect survival in patients with a primary diagnosis of head and neck mucoepidermoid carcinomas.

This overexpression may be due to the process envolving histogenesis and celular mucoepicermoide. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License.

Tumors were stratified into three groups: Histologically, the tumors were classified as low, intermediate and high grade, according to Auclair et al. International histological classification of tumours.

Published works usually lose relevant glanfulas information through time.