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Histone Methyltransferase Signaling Pathway Map. MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice.
Chemical formula is case sensitive. To calculate molar mass of a vatasheet compound, please enter its chemical formula and click ‘Calculate’. MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker.
These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs. Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues. Calculate the dilution required to prepare a stock solution.
References  Borkin D, et datasheer.
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The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment. Menin-MLL interaction  Cell-free assay. The Selleck dilution calculator is based on the following equation: Not for human use. Answers to questions you may have can be found in the inhibitor handling instructions.
Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution. For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0.
This is normal and is due to slight batch-to-batch variations. Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:.
Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b dafasheet before being analyzed by flow cytometry.
It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell bct GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations. Products are for research use only.
In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. Calculate the mass, volume or concentration required for a solution.
Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u. MI could substantially improve survival of Datasueet leukemic mice and does not impair normal hematopoiesis in vivo .
Choose Selective Histone Methyltransferase Inhibitors.
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The Selleck molarity calculator is based on the following equation: Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias . We do not sell to patients.
The Selleck molarity calculator is based on the following equation:. This equation is commonly abbreviated as: It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden.
Molecular Weight Calculator Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Serial Eatasheet Concertration start: