Fairbrother KJ, Heasman PA: Anticalculus agents. J Clin Periodontol ; the research associated with the development of anticalculus agents and to evalu-. Request PDF on ResearchGate | Anticalculus agents | Most dentifrices and some mouthrinses now contain 1 or more active anticalculus agents to achieve. With the help of antiplaque and anticalculus agents. Chemical plaque control – Rationale. Gingivitis & periodontitis are highly prevalent diseases and.

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As used herein, percentages listed are weight percentage of composition unless otherwise specified. Country of ref document: Application frequency is preferably from about 3 times weekly to about 4 times daily, more preferably from about once daily to about 3 times daily, more preferably still from about once to about twice daily. In this way, delivery of the antibacterial biphenol compounds is significantly improved thereby allowing increase in antiplaque activity of the oral composition or enabling a reduction in the amount of the antibacterial biphenol compound needed to achieve antiplaque activity.

However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution. Additionally, tetrahydromagnolol and tetrahydrohonokiol are hydrogenated analogs of magnolol and honokiol often found in relatively small concentrations in the extracts of magnolia, and as such may be included in the antibacterial ingredient.

Surfactants may also be used as solubilizing agents to help retain sparingly soluble components, e.

In fact, if anything, the addition of a zinc ion source such as zinc oxide to compositions according to the present invention improves the delivery of the biphenol compound. In certain embodiments of the present invention, the antibacterial ingredient in the active composition comprises one or more active agentss that have been isolated from an extract of magnolia.

The oral care composition of claim 1, wherein the anticalculus agent consists essentially of a zinc ion source. Useful surfactants include anionic surfactants such as the water-soluble salts of alkyl sulfates having 10 to 18 carbon atoms in the alkyl radical and the water-soluble salts of sulfonated monoglycerides of fatty acids having 10 to 18 carbon atoms. The compositions must be at a pH which is safe for contact with the tissues of the.


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Another optional component of xnticalculus oral carriers of the compositions of this invention is a humectant. If added, the antibacterial active ingredients it is desirable that the additive does not substantially detract from the efficacy and bioavailability of the tartar control agents or the active compound of the extract.

While the addition sodium sulfate alone Formula 11 did not impact anticalculjs delivery, such delivery was slightly improved in the presence of Zinc oxide Formula Oral care compositions according to the invention must be free at anticalclus of tetrasodium pyrophosphate. The amount of citrate anion suitable for the purposes of this invention is from about 0. This is especially true for many anticalculus systems. In dentifrice compositions, the preferred amounts of citrate anion are from about 0.

Anti-plaque and Anti-calculus Oral Care Product Testing

Water employed in the preparation of the commercially suitable compositions should preferably be of low ion content and free of organic impurities. After one week he receives dental prophylaxis performed by his dentist. Suitable bleaching agents include organic and inorganic oxidizing agents such as hydrogen peroxide, alkali metal peroxides and superoxide and organic peroxides such as monoper- oxyphthalates and perbenzoic derivatives.

The digestion produces both by-products which add to the plaque, and produces acid which erodes tooth enamel.

Anticalculus agents.

Other operative polymeric polycarboxylates include those disclosed in U. In common with other carrier components, in certain embodiments, the surfactant should be phosphate-free.

Quantitative HPLC is performed by comparison with suitable standard solutions and the concentration of active substance on the disk is determined. During manufacture, the pH of the following. Dental abrasives useful in the topical, oral carriers of the compositions of this invention include many different materials.

EP Agentts code of ref document: Anti-sensitivity, anti-caries, anti-staining, anti-plaque, ultra-mild oral hygiene agent. Regular brushing aids in preventing a rapid build-up of these deposits, but even regular brushing is not sufficient to remove all anticwlculus the calculus deposits which adhere to the teeth.

Date of ref document: Phosphate-free oral care compositions based on Magnolia derived antibacterials.

Anticalculus agents.

Replacing the phosphate containing anticalculus agent with a phosphate-free anticalculus agent such as a zinc salt provides an oral care composition which has anticalculus properties and enhanced uptake of the antibacterial component. The effectiveness of different agents can thereby be compared. Another aspect of this invention involves methods of treating or preventing mouth odor, dental agenst, calculus and gingivitis, by application of compositions comprising a safe and effective amount of Actives, to tissues of the oral cavity.


In Vitro Laboratory Support Studies. Preferred precipitated silica materials include those marketed by the J. B01A Ref document number: Such compositions include mouthwashes, mouth rinses, mouth sprays, dental treatment solutions, toothpastes, liquid dentifrices and the like and are more fully described hereinafter.

At the end of one week, the person received dental prophylaxis and rinses for thirty seconds twice daily with 12 ml of the composition of Example XIII. An oral care composition for treating or preventing calculus comprising an anticalculus agent and an antibacterial agent comprising a biphenol compound obtainable from Magnolia officinaliswherein the composition is free of phosphate-containing anticalculus agents.

The examples are given solely for illustration and are not to be construed as limitations of this invention as many variations are possible without departing from the spirit and scope of this invention. Such components include, but are not limited to, anticaries agents, antiplaque agents, anticalculus agents, dental abrasives, surfactants, flavoring agents, sweetening agents, binders, humectants, thickening agents, buffering agents, preservatives, coloring agents and pigments, ethanol and water.

When the oral composition is a toothpaste, preferably from about 0. The term “comprising”, as used herein, anticalcuuls that various additional components can be conjointly employed in the compositions of this invention.

Periodontitis is a progressively worsened state of disease as compared to agente. Preparation for prevention of emission of mercury from amalgam fillings and method. After eight weeks, the person has significantly less calculus on her teeth agehts she did after the first eight weeks, using the non-anticalculus mouth rinse. When Zinc oxide was also added to the formula, delivery of Magnolol is further slightly improved.

EXAMPLE XV Following dental prophylaxis, a person rinses her mouth for twenty seconds twice daily for a period of eight weeks using 10 ml of a non-anticalculus mouth rinse. The composition of any of Claims comprising a binder which is non-ionic at the formulation pH of the composition.